Working Paper. Katharine Hankus, MA. It is a serious disease causing lifelong disability and a significantly increased risk of mortality. Recent research has highlighted the microbiome as a cause — and treatment — for numerous diseases, including epilepsy. We propose the GAPS nutritional protocol as a therapeutic target for epilepsy because it takes a necessary multifaceted approach to treating the factors that result in epilepsy. The GAPS nutritional protocol decreases intestinal permeability and pathogenic immune responses while rebalancing gut microbiota and treating dysbiosis. Furthermore, recent insight into the mechanisms of action of the ketogenic diet show that it is not the ketones that provide anti-seizure effects, but rather an alteration of intestinal microbiota, anti-inflammatory side effects, and inclusion of medium-chain triglycerides.
I hang out sometimes on a forum for parents of children with epilepsy. If there are kids whose seizures are controlled by medication and who are doing well — or even making it through the day — in school, their parents are posting somewhere else. The treatment that parents tell each other about most often is the ketogenic diet — and its cousins, the modified Atkins, low glycemic index, and specific carbohydrate diets. The ketogenic diet has been tested repeatedly — including a recent RCT that demonstrated its efficacy at helping children with intractable seizures despite multiple medications. But, as far as I can tell, most parents still learn about it from each other, not their physicians. The ketogenic diet induces long-term ketosis, a condition in which the body converts fat into energy instead of carbohydrates, by extreme dietary modifications. The mechanism behind its effectiveness might be an increase in leptin.
In particular, a mouse model shows a correlation between fructose and the reduction in tight junction proteins occludin and ZO-1 while fructose simultaneously increased a bacterial endotoxin in the portal vein . ET, the Emmy-nominated Brain Games tv-show is back! Classic Keto. Nutrition Reviews. It was the same scenario, falling and then quickly recovering. The Modified Atkins diet has helped many people with intractable seizures and is often the standard recommended therapy when patients fail several anti-seizure medications.